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. Author manuscript; available in PMC: 2011 Mar 30.
Published in final edited form as: Oncogene. 2010 Jul 19;29(39):5359–5369. doi: 10.1038/onc.2010.274

Fig. 4. Jak2 deficiency does not affect the growth of PRL-induced mammary cancer cells in vivo.

Fig. 4

(a) Growth of PRL-induced mammary cancer cells lacking Jak2 and their isogenic controls in an orthotropic transplant of Athymic nude mice. (b) PCR assay to verify the presence of Jak2 floxed alleles or Jak2 null alleles in resulting mammary tumors following orthotropic transplantation. Note that the Jak2 wildtype allele (Jak2wt), which was present in the PCR assay in both experimental groups, originated from stromal cells and blood vessels of the wildtype host. This allele was not present in the engrafted Jak2fl/fl or Jak2-/- cancer cells. NC: negative control.