. Author manuscript; available in PMC: 2010 Dec 6.

Published in final edited form as: Cell Ther Transplant. 2010 Aug 31;2(8):10.3205/ctt-2010-en-000077.01. doi: 10.3205/ctt-2010-en-000077.01

Table 4.

Intensity conditioning regimens and transplant outcome in immunodeficiency syndromes

Author	Diagnosis	Regimen	Donor	Rejection (No.)	Survival (No.)	FU (mo)
Reduced Intensity Conditioning
(Rao et al. 2005 [67])	27 PID/ 6 SCID	Flu/ Mel/Campath	BM	0	31
(Amrolia et al. 2000 [68])	6 ID/ 2 SCID	Flu/ Mel/ ATG		0	7	6-18
(Rao et al. 2007 [38])	4 IPEX	Flu/ Mel/Campath	BM	0	4	6-25
(Cohen et al. 2007 [69])	7 PID/ EBV-LPD	Flu/ Mel/Campath	BM or PBSC	0	7	0
Minimal Toxicity (non-myeloablative) Conditioning
(Horwitz et al. 2001 [70])	10 CGD	Flu/ Cy/ ATG Post-HCT DLI	CD34+ PBSC	1	7	16-26
(Burroughs et al. 2007 [71])	10 PID+SC-M	Flu / 2 Gy TBI	PBSC	1	7	9-96

Abbreviations: ATG, anti-thymocyte globulin; BM, bone marrow; CB, cord blood; CGD, chronic granulomatous disease; DLI, donor lymphocyte infusion; EBV-LPD, Epstein Barr virus lymphoproliferative disease; Flu, fludarabine; HCT, hematopoietic cell transplant; IPEX, Immunodeficiency-polyendocrinopathy-enteropathy X-linked; Mel, melphalan; MSD, matched sibling donor; PBSC, peripheral blood stem cells; PID, primary immune deficiency (nonSCID); SCID, severe combined immune deficiency; SC-M, severe co-morbities; TBI, total body irradiation