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. 2010 Dec 6;5(12):e15167. doi: 10.1371/journal.pone.0015167

Figure 2. The effects of LMNA E82K on heart dimensions and hypertrophic marker expression in the transgenic mice.

Figure 2

(A) Heart weight to body weight ratio was determined (n = 14, ‡ P<0.01 versus NTG mice). (B) Representative M-mode echocardiographic images of the LV long-axis of the NTG and Lmna E82K transgenic mice. (C) H&E staining patterns of the whole-heart longitudinal sections from 6 months old NTG and Lmna E82K transgenic mice (magnification ×20). (D) Magnification of H&E stained sections of LV (magnification ×400). (E) Magnification of Masson trichrome stained sections of LV in NTG and Lmna E82K transgenic mice (magnification ×400). (F) Expression of Actα1, ANP, BNP and Col3α1 were detected by western blot and RT-PCR procedure using GADPH as normalization.