Table 7.

Estimated cumulative cancer incidence and mortality attributed to various breast imaging procedures and background radiation, compared to the potential number of lives saved assuming a 15%, 14%, and 32% reduction in mortality from screening mammography for a normal population of women aged 40–49, 50–59, and 60–80, respectively, and assuming a 15% reduction for all women aged 40–80 with dense breast tissue.

Procedure∕exposure source	Dose	Exposure period (yr)	Cancers induced	Cancer deaths	Reduction in mortality	Benefit∕risk ratio
Digital mammography	3.91 mGy	40–80	56	15	845	56:1
Normal population	3.91 mGy	50–80	21	6	815	135:1
	3.91 mGy	40–49	35	9	31	∼3:1
Screen-film mammography	4.98 mGy	40–80	71	19	845	44:1
	4.98 mGy	50–80	27	7	815	116:1
Normal population	4.98 mGy	40–49	44	11	31	∼3:1
Digital mammography	3.91 mGy	40–80	56	15	1129	75:1
Dense breast population	3.91 mGy	50–80	21	6	1051	175:1
	3.91 mGy	40–49	35	9	78	9:1
Screen-film mammography	4.98 mGy	40–80	71	19	1129	59:1
	4.98 mGy	50–80	27	7	1051	150:1
Dense breast population	4.98 mGy	40–49	44	11	78	7:1
MBIa	925 MBq	40–80	782	453	2408	∼5:1
Tc-99m sestamibi	925 MBq	50–80	460	267	2241	∼8:1
Dense breast population	925 MBq	40–49	322	186	167	∼1:1
Low-dose MBIa	111 MBq	40–80	94	54	2408	46:1
Tc-99m sestamibi	111 MBq	50–80	55	34	2241	66:1
Dense breast population	111 MBq	40–49	39	20	167	∼8:1
PEM	370 MBq	40–80	800	408	No data
F-18 FDG	370 MBq	50–80	442	248	No data
	370 MBq	40–49	358	160	No data
Background radiation	3.1 mSv	0–80	2174	1011	—

^aEstimates for MBI assume a 32% reduction in mortality from MBI for all women ages 40–80 with dense breast tissue. No data on screening is available for BSGI or PEM. All numbers are cumulative to age 80 for 100 000 females.