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Selected examples of SPR-based detection of cancer biomarkers
| Biomarker | Amplification | Assay type | DL | Ref. |
|---|---|---|---|---|
| VEGF | Precipitation | RNA–aptamer microarrays | 45 pg mL−1 | 53 |
| PSA | Au-NP | Ab1/PSA/Ab2–biotin/streptavidin–AuNP | 1 ng mL−1 | 75 |
| p53 | None | SPR binding assay | 0.2–0.5 ng mL−1 | 76 |
| IL-6 | None | Protein A/Ab1/IL6/IL6 receptor | 3.75 ng mL−1 | 77 |
| IL-8 | None | Ab1/IL8/Ab2 | <2 ng mL−1 | 78 |
| PSA | DNA barcode | Ab1–NP/Ab2–magnetic microparticles | 30 aM PSA | 79 |
