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. Author manuscript; available in PMC: 2011 Dec 5.
Published in final edited form as: Chem Biol Interact. 2010 Oct 20;188(3):512–525. doi: 10.1016/j.cbi.2010.09.018

Figure 2. RQSAR for group B - Phthaleins.

Figure 2

(A) 2D structures of group B phthaleins. (B) CAR3-driven relative luciferase activity, (C) CAR1, and (D) PXR treated with 10 µM test compound, plotted using log scales. 0 = DMSO solvent control. Cotreatments were PK11195 (10 µM) for CAR1 and rifampicin (25 µM) for PXR. (n=4 except for B: B1 n=7, B2–8 n=8. C: B1 n=3).