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. Author manuscript; available in PMC: 2011 Dec 5.
Published in final edited form as: Chem Biol Interact. 2010 Oct 20;188(3):512–525. doi: 10.1016/j.cbi.2010.09.018

Table 2.

Relative luciferase activity values for CAR1, CAR3 and PXR treated with group B compounds (Phthaleins).

CAR3 CAR1 PXR
Control PK11195 Control Rifampicin
ID Chemical Name Value Siga Value Sig Value Sig Value Sig Value Sig
0 Solvent control 1.00 - 1.00 - 0.76 - 1.00 - 2.35 -
B1 Phenolphthalein 84.96 *** 0.90 * 0.71 - 1.76 *** 1.68 -
B2 Cresolphthalein 0.94 - 0.92 * 0.72 - 1.11 - 1.80 -
B3 Cresol Red 1.10 - 0.97 - 0.73 - 0.96 - 2.13 -
B4 Bromocresol Purple 0.95 - 0.99 - 0.74 - 0.82 * 1.82 -
B5 Thymolphthalein 0.67 *** 0.45 *** 0.39 *** 0.51 *** 0.38 ***
B6 Thymol Blue 1.03 - 0.89 ** 0.72 - 1.77 *** 1.97 -
B7 Bromothymol Blue 0.91 - 0.90 ** 0.71 - 1.70 ** 2.07 -
B8 α-Naphtholphthalein 52.92 *** 1.05 - 0.85 - 2.51 *** 1.87 -
a

Sig = significance in unpaired t-test

Inline graphic Significant agonist effect

Inline graphic Significant inverse agonist/antagonist effect

*

0.01 < p < 0.05;

**

0.001 < p < 0.01;

***

p < 0.001