Table 3.
Relative luciferase activity values for CAR1, CAR3 and PXR treated with group C compounds (Alkylphenols).
| CAR3 | CAR1 | PXR | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Control | PK11195 | Control | Rifampicin | ||||||||
| ID | Chemical Name | Value | Siga | Value | Sig | Value | Sig | Value | Sig | Value | Sig |
| 0 | Solvent control | 1.00 | - | 1.00 | - | 0.76 | - | 1.00 | - | 2.35 | - |
| C1 | 4-Ethylphenol | 0.97 | - | 0.97 | - | 0.49 | * | 0.90 | - | 1.72 | - |
| C2 | 4-Propylphenol | 0.81 | - | 0.93 | - | 0.62 | - | 0.98 | - | 1.86 | - |
| C3 | 4-tert-Butylphenol | 1.23 | - | 0.82 | ** | 0.65 | - | 1.06 | - | 2.30 | - |
| C4 | 4-Pentylphenol | 1.17 | - | 0.93 | - | 0.68 | - | 1.09 | - | 2.39 | - |
| C5 | 4-Hexylphenol | 1.62 | * | 0.88 | * | 0.75 | * | 1.05 | - | 2.32 | - |
| C6 | 4-Octylphenol | 1.15 | - | 0.87 | ** | 0.68 | - | 0.99 | - | 2.25 | - |
| C7 | 4-Octyloxyphenol | 1.14 | - | 0.76 | * | 0.53 | - | 0.96 | - | 2.12 | - |
| C8 | 4-Nonylphenol | 117.14 | *** | 1.97 | *** | 1.26 | *** | 2.28 | *** | 1.94 | - |
| C9 | Nonylbenzene | 2.48 | * | 0.99 | - | 0.76 | - | 1.04 | - | 2.29 | - |
| C10 | 1-Nonanol | 6.64 | ** | 1.11 | ** | 0.76 | - | 1.01 | - | 2.02 | - |
| C11 | 3-Pentadecylphenol | 2.26 | *** | 1.38 | *** | 1.13 | ** | 0.91 | - | 2.34 | - |
a
Sig = significance in unpaired t-test
Significant agonist effect
Significant inverse agonist/antagonist effect
*
0.01 < p < 0.05;
**
0.001 < p < 0.01;
***
p < 0.001