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. Author manuscript; available in PMC: 2011 Dec 5.

Published in final edited form as: Chem Biol Interact. 2010 Oct 20;188(3):512–525. doi: 10.1016/j.cbi.2010.09.018

Table 4.

Relative luciferase activity values for CAR1, CAR3 and PXR treated with group D compounds (Stilbenes).

		CAR3		CAR1				PXR
				Control		PK11195		Control		Rifampicin
ID	Chemical Name	Value	Sig^a	Value	Sig	Value	Sig	Value	Sig	Value	Sig
0	Solvent control	1.00	-	1.00	-	0.76	-	1.00	-	2.35	-

D1	trans-Stilbene	1.56	^***	1.14	^*	0.86	^**	1.59	^***	3.08	-
D2	trans-Stilbene oxide	1.09	-	1.00	-	0.75	-	1.44	^***	2.54	-
D3	Hexestrol	37.98	^***	1.21	^**	0.93	-	1.66	^***	2.57	-
D4	Diethylstilbestrol	95.11	^***	1.08	^*	0.80	-	1.55	^***	2.08	-
D5	Resveratrol	0.67	^***	1.71	^***	1.48	^***	1.54	^*	2.71	-
D6	Pterostilbene	1.02	-	1.31	^***	1.11	^***	1.69	^**	3.07	-

^a

Sig = significance in unpaired t-test

Inline graphic Significant agonist effect

Inline graphic Significant inverse agonist/antagonist effect

^*

0.01 < p < 0.05;

^**

0.001 < p < 0.01;

^***

p < 0.001