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. Author manuscript; available in PMC: 2011 Dec 5.
Published in final edited form as: Chem Biol Interact. 2010 Oct 20;188(3):512–525. doi: 10.1016/j.cbi.2010.09.018

Table 5.

Relative luciferase activity values for CAR1, CAR3 and PXR treated with group E compounds (Diphenyls).

CAR3 CAR1 PXR
Control PK11195 Control Rifampicin
ID Chemical Name Value Siga Value Sig Value Sig Value Sig Value Sig
0 Solvent control 1.00 - 1.00 - 0.76 - 1.00 - 2.35 -
E1 2-Benzylphenol 0.79 - 0.93 - 0.66 - 1.13 - 2.50 -
E2 4-Benzylphenol 0.80 - 1.02 - 0.83 - 1.14 - 2.42 -
E3 Bis(4-hydroxyphenyl)methane 1.69 - 1.06 * 0.83 ** 1.00 - 2.13 -
E4 4-Cumylphenol 222.05 *** 1.03 - 0.76 * 2.04 ** 2.09 -
E5 BPA [Bisphenol A] 71.17 *** 1.10 - 0.87 - 1.68 *** 2.43 -
E6 BPA dimethylether 4.16 *** 1.15 *** 0.88 - 1.35 *** 2.17 **
E7 BPA diacetate 381.41 *** 0.96 ** 0.71 * 1.51 ** 2.39 -
E8 BADGE [BPA diglycidylether] 0.88 * 0.81 - 0.81 * 1.39 *** 2.41 -
E9 BPA dimethacrylate 351.40 *** 1.31 *** 0.84 - 1.48 ** 2.49 -
E10 Bisphenol Z [4,4′-Cyclohexylidenebisphenol] 811.70 *** 1.39 *** 1.03 *** 2.25 *** 2.58 -
E11 BPA, tetramethyl [4,4′-isoproplyidene bis(2,6-dimethylphenol)] 9.97 *** 0.71 *** 0.80 - 2.29 ** 1.86 *
E12 Bisphenol AF [4,4′-(Hexafluroisoproplyidene)diphenol] 821.46 *** 1.33 *** 1.01 *** 1.20 * 1.77 **
E13 4,4′-Dihydroxydiphenyl ether 0.86 - 0.95 - 0.81 - 1.03 - 2.18 -
E14 Bisphenol S [4,4′-Sulfonyldiphenol] 2.09 - 1.01 - 0.77 - 0.69 *** 2.16 -
a

Sig = significance in unpaired t-test

Inline graphic Significant agonist effect

Inline graphic Significant inverse agonist/antagonist effect

*

0.01 < p < 0.05;

**

0.001 < p < 0.01;

***

p < 0.001