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. Author manuscript; available in PMC: 2011 Dec 5.
Published in final edited form as: Chem Biol Interact. 2010 Oct 20;188(3):512–525. doi: 10.1016/j.cbi.2010.09.018

Table 6.

Relative luciferase activity values for CAR1, CAR3 and PXR treated with group F compounds (Antihistamines and Antifungals).

CAR3 CAR1 PXR
Control PK11195 Control Rifampicin
ID Chemical Name Value Siga Value Sig Value Sig Value Sig Value Sig
0 Solvent control 1.00 - 1.00 - 0.76 - 1.00 - 2.35 -
F1 Diphenhydramine 1.16 - 0.97 - 0.61 ** 0.97 - 2.25 -
F2 Doxylamine 1.68 * 1.03 - 0.63 - 0.85 - 1.78 -
F3 Pheniramine 5.84 *** 1.01 - 0.66 - 0.82 - 2.07 -
F4 Cetirizine 1.15 - 1.01 - 0.77 - 0.96 - 2.16 -
F5 Fexofenadine 1.19 - 0.99 - 0.76 - 0.90 - 1.88 *
F6 Loperamide 1.15 - 0.86 ** 0.59 ** 1.06 - 1.10 **
F7 Ketoconazole 1.30 - 0.61 *** 0.55 *** 0.98 - 1.45 ***
F8 Fluconazole 1.13 - 1.00 - 0.77 - 1.08 - 2.22 -
a

Sig = significance in unpaired t-test

Inline graphic Significant agonist effect

Inline graphic Significant inverse agonist/antagonist effect

*

0.01 < p < 0.05;

**

0.001 < p < 0.01;

***

p < 0.001