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. Author manuscript; available in PMC: 2011 Oct 14.
Published in final edited form as: Cytokine Growth Factor Rev. 2010 Oct 14;21(5):393–401. doi: 10.1016/j.cytogfr.2010.09.001

Figure 5.

Figure 5

The IL-20R1 gene, IL20RA, encodes several RNA splice variants. Three variants of the IL-20R1 gene can be expressed in cells that express this receptor chain. The first is the full-length 3.6 kb transcript (GenBank accession no. NM_014432) that encodes the complete receptor polypeptide, including both fibronectin type-III (FnIII) domains of the extracellular region. The second is a 1.7 kb variant (GenBank accession no. AY358883) that lacks the membrane-distal FnIII domain, but retains the membrane-proximal FnIII domain, the trans-membrane domain, and the complete intracellular region. This variant arises as a result of deletion of most of exon 1 and all of exon 3. The third transcript is a 1.9 kb variant (GenBank accession no. AK098312) that lacks the entire extracellular region, but retains a small part of the trans-membrane domain and the complete intracellular domain. This variant arises as a result of the complete deletion of exons 1, 2 and 3. Although the full-length (3.6 kb) transcript encodes a functional IL-26-binding protein, the functions of the shorter 1.7 kb and 1.9 kb variants are unknown.