Table 2.

Susceptibility Genes for RA

Chromosome	Gene	SNPs	Population	Reference
6p21.32	HLA-DRB1	rs615672, rs660895, rs64576200, rs6910071, rs13192471	European, Japanese	[21–25]
1p13.2	PTPN22	rs6679677, rs2476601	European	[21–24,30]
2q32.3	STAT4	rs7574865	European, Japanese	[24,25]
9q34	TRAF1-C5	rs3761847, rs881375	European	[22,24,30]
6q23.3	TNFAIP3, OLIG3	rs10499194, rs6920220	European, Japanese	[23–25,29]
6p21.32	HLA-DQA1, HLA-DQA2	rs6457617	European	[31]
18q23	SALL3	rs2002842	European	[31]
20q13.12	CD40	rs4810485	European	[23,24]
9p13.3	CCL21	rs2812378	European	[23]
12q13.3	KIF5A, PIP4K2C	rs1678542	European	[23]
1p36.32	TNFRSF14	rs3890745	European	[23,24]
10p15.1	PRKCQ	rs4750316	European	[23,24]
7q21.2	CDK6	rs42041	European	[23]
2p16.1	REL	rs13017599, rs13031237	European	[24,30]
2q33.2	CTLA4	rs231735, rs3087243	European	[24,30]
8p23.1	BLK	rs2736340	European	[30]
2q11.2	AFF3	rs11676922, rs10865035	European	[24]
5q11.2	ANKRD55, IL6ST	rs6859219	European	[24]
14q24.3	BATF	rs7155603	European	[24]
5q21.1	C5orf30	rs26232	European	[24]
9p13.3	CCL21	rs951005	European	[24]
6q27	CCR6	rs3093023, rs3093024	Japanese	[24,25]
1q24.2	CD247	rs840016	European	[24]
17q12	IKZF3	rs2872507	European	[24]
4q27	IL2, IL21	rs13119723	European	[24]
10p15.1	IL2RA	rs706778	European	[24]
7q32.1	IRF5	rs10488631	European	[24]
15q23	KIF3	rs17374222	European	[24]
1p34.3	POU3F1	rs12131057	European	[24]
3p14.3	PXK	rs13315591	European	[24]
4p15.2	RBPJ	rs874040	European	[24]
12q24.12	SH2B3	rs3184504	European	[24]
2p14	SPRED2	rs934734	European	[24]
21q22.3	UBASH3A	rs11203203	European	[24]