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. Author manuscript; available in PMC: 2011 Dec 1.
Published in final edited form as: Curr Opin Chem Biol. 2010 Dec;14(6):728–736. doi: 10.1016/j.cbpa.2010.07.021

Figure 4.

Figure 4

A schematic representation of a sensor element in the sensor comprised of β-galactosidase (β-Gal) and cationic AuNPs and differentiation of proteins in 3-D. a) As shown, β-gal is displaced from the β-Gal/AuNP complex by protein analytes, restoring the catalytic activity of β-Gal towards the fluorogenic substrate 4-methylumbelliferyl-β-D-galactopyranoside, resulting in an amplified signal for detection. b) Differential protein pattern of the nine proteins at 1 nM. c) Canonical score plot of the first three factors of fluorescence response patterns obtained through β-Gal/AuNP sensor array against nine target proteins in 1 nM concentration [32].