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Top row: TEM micrographs of macrophage-internalized LEVs 24 hrs after particle introduction. LEVs were sparsely-loaded with 10 nm (left, 100k) or 30 nm (right, 25k) chitosan-coated nanoparticles (IO-chitosan). Bottom quadrant: Time sequence of events for endosomal escape of 30 nm chitosan-SPIONs [25k (top row); 50k (bottom left) and 100k (bottom right)].
