. Author manuscript; available in PMC: 2011 Dec 6.

Published in final edited form as: Mol Pharm. 2010 Nov 11;7(6):2362–2368. doi: 10.1021/mp100300k

Table 1.

Estimated half-life values of valine and phenylalanine analogues in pH 7.4 HEPES buffer (mean ± SEM; esters, n=3; Val-3-APG, n=1).

valine analogues	t_1/2 (min)^a	phenylalanine analogues	t_1/2 (min)^a
valine p-nitrobenzyl ester	412.3 ± 11.9	Phe-3-HPG	230.0 ± 6.5
Val-3-HPG	486.9 ± 6.6	Phe-OBn	365.0 ± 9.4
valacyclovir	742.1 ± 5.5	Phe-OMe	470.6 ± 12.6
Val-OBn	857.8 ± 7.6	Phe-OEt	1006.4 ± 26.0
Val-3-APG	6.2 × 10⁷

All the groups are statistically different.