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. Author manuscript; available in PMC: 2012 Apr 15.
Published in final edited form as: Int J Cancer. 2011 Apr 15;128(8):1836–1842. doi: 10.1002/ijc.25524

Figure 4. Model for transcriptional repression of αSSeCKS by Src.

Figure 4

In NIH3T3 cells, the transcription factors USF1 and Sp1/Sp3 bind to their cognate αSSeCKS proximal promoter sites and activate SSeCKS transcription. In Src/3T3 cells, tyrosine phosphorylated TFII-I (induced by Src) binds to the αSSeCKS proximal promoter complex, which also contains the co-repressor HDAC1 (which is recruited via elevated Sp1/Sp3 binding), resulting in the transcriptional repression of αSSeCKS.