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A: Structural features of two types of activity based probes are shown. Probe MTS-I-94 targets serine proteases. It is composed of phosphonate warhead, a cleavable diazo linker and a biotin tag. DCG-04 is a cysteine protease probe with epoxide warhead.
B: Probes that target serine and cysteine proteases irreversibly and covalently bind to the active site nucleophile (serine or cysteine).
