Table 2.
Time (h) | Group | Grade | Median | Significance | Event |
2 | D1 | 0, 2, 6, 7 | 4 | Denuded villi | |
D2 | 3, 4, 6, 6 | 5 | Loss of villi | ||
D3 | 1, 2, 2, 3 | 2 | D3, D4, D5 vs D1, D2, P = 0.06 | Moderate clefting | |
D4 | 1, 2, 3, 5 | 2.5 | Moderate-extensive clefting | ||
D5 | 1, 2, 3, 4 | 2.5 | Moderate-extensive clefting | ||
12 | D1 | 0, 6, 7, 8 | 6.5 | Injury to crypts and submucosa | |
D2 | 2, 6, 7, 7 | 6.5 | Injury to crypts and submucosa | ||
D3 | 3, 7, 8, 8 | 7.5 | Injury to crypts, submucosa and muscularis | ||
D4 | 3, 6, 8, 8 | 7 | Injury to crypts and submucosa | ||
D5 | 0, 4, 4, 5 | 4 | D5 vs D1-D4, P < 0.05 | Clefting and denuded villi |
A modified Park’s classification for intestinal injury was used to assess mucosal morphology as follows: Grade 0: Normal mucosa; Grade 1: Subepithelial space at villus tip; Grade 2: Moderate subepithelial space; Grade 3: Epithelial lifting along villus sides; Grade 4: Denuded villi; Grade 5: Loss of villus tissue; Grade 6: Crypt layer injury; Grade 7: Transmucosal injury; Grade 8: Transmural injury.