. Author manuscript; available in PMC: 2010 Dec 6.

Published in final edited form as: Arthritis Rheum. 2009 Dec;60(12):3794–3806. doi: 10.1002/art.24958

Table 2.

Distribution of TBX21 and STAT4 SNP genotypes in North American white control subjects and patients with SSc^*

		SSc Registry cohort					UT Division cohort					Mantel-Haenszel–combined cohorts
SNP (minor allele)	Position, bp	MAF		OR	P^†	P^‡	MAF		OR	P^†	P^‡	OR (95% CI)^†	P^†	OR (95% CI)^‡	P^‡
SNP (minor allele)	Position, bp	Controls	SSc	OR	P^†	P^‡	Controls	SSc	OR	P^†	P^‡	OR (95% CI)^†	P^†	OR (95% CI)^‡	P^‡
TBX21 ^§
rs9910408 (G)	43157873	0.44	0.40	0.83	0.14	0.06	0.40	0.45	1.22	0.01	0.10	0.96 (0.8–1.2)	0.65	0.97 (0.8–1.1)	0.66
rs11079786 (T)	43160915	0.26	0.28	1.09	0.72	0.42	0.31	0.31	1.01	0.51	0.97	1.07 (0.9–1.3)	0.52	1.05 (0.9–1.2)	0.52
rs4794067 (G)	43163827	0.26	0.29	1.13	0.54	0.29	0.29	0.30	1.04	0.61	0.77	1.11 (0.9–1.4)	0.33	1.09 (0.9–1.3)	0.32
rs2240017 (G)	43165918	0.03	0.03	0.84	0.52	0.53	0.04	0.03	0.71	0.64	0.32	0.78 (0.5–1.2)	0.27	0.78 (0.5–1.2)	0.26
rs2074190 (C)	43166209	0.25	0.28	1.16	0.47	0.26	0.30	0.30	1.01	0.73	0.97	1.10 (0.9–1.4)	0.41	1.08 (0.9–1.3)	0.41
rs10514934 (G)	43167123	0.11	0.12	1.14	0.68	0.39	0.12	0.13	1.04	0.01	0.82	1.11 (0.9–1.4)	0.43	1.10 (0.9–1.4)	0.42
rs16946264 (T)	43168433	0.10	0.10	0.91	0.75	0.54	0.13	0.08	0.64	0.01	0.02	0.78 (0.6–1.01)	0.06	0.79 (0.6–1.01)	0.06
rs11650354 (T)	43177091	0.15	0.18	1.29	0.002	0.08	0.16	0.22	1.49	0.02	0.01	1.44 (1.1–1.8)	0.006	1.38 (1.1–1.7)	0.003
rs11657479 (C)	43177900	0.22	0.25	1.24	0.12	0.06	0.25	0.29	1.22	0.35	0.13	1.29 (1.1–1.6)	0.016	1.23 (1.04–1.5)	0.015
rs7502875 (C)	43178226	0.21	0.24	1.17	0.29	0.17	0.24	0.27	1.14	0.63	0.32	1.19 (0.97–1.5)	0.10	1.16 (0.98–1.4)	0.09
rs16947058 (T)	43180185	0.42	0.42	0.99	0.99	0.94	0.46	0.45	0.94	0.93	0.71	0.97 (0.8–1.2)	0.78	0.97 (0.8–1.1)	0.71
rs16947078 (G)	43180499	0.20	0.22	1.10	0.70	0.40	0.23	0.23	1.00	0.77	0.97	1.07 (0.9–1.3)	0.51	1.06 (0.9–1.3)	0.50
rs17699436 (G)	43183574	0.11	0.08	0.72	0.10	0.04	0.10	0.06	0.55	0.02	0.01	0.64 (0.5–0.8)	0.002	0.66 (0.5–0.9)	0.001
STAT4 ^¶
rs11889341 (A)	191651987	0.22	0.26	1.30	0.03	0.01	0.24	0.28	1.22	0.36	0.14	1.33 (1.1–1.6)	0.005	1.27 (1.1–1.5)	0.004
rs7574865 (A)	191672878	0.21	0.26	1.31	0.03	0.01	0.25	0.28	1.18	0.48	0.21	1.34 (1.1–1.6)	0.005	1.26 (1.1–1.5)	0.004
rs8179673 (C)	191677586	0.22	0.27	1.36	0.01	0.003	0.25	0.29	1.20	0.39	0.16	1.37 (1.1–1.7)	0.002	1.30 (1.1–1.5)	0.001
rs10181656 (C)	191678124	0.22	0.27	1.33	0.02	0.01	0.25	0.29	1.21	0.37	0.15	1.37 (1.1–1.6)	0.002	1.29 (1.1–1.5)	0.002
rs6752770 (C)	191681808	0.29	0.30	1.05	0.49	0.59	0.28	0.37	1.50	0.004	0.001	1.25 (1.1–1.5)	0.017	1.20 (1.03–1.4)	0.02

Odds ratios (ORs) and 95% confidence intervals (95% CIs) are for carriage of the minor allele genotype. Control subjects were used as reference for all comparisons. SNP = single-nucleotide polymorphism; SSc = systemic sclerosis; MAF = minor allele frequency; UT Division cohort = University of Texas SSc cohort.

^†

Genotypic 3 × 2 chi-square comparison.

^‡

Allelic comparison.

^§

Chromosome 17.

^¶

Chromosome 2.