FIGURE 7.
Transplantation of ACE10/10 bone marrow into WT mice confers increased resistance to MRSA. Recipient C57BL/6 mice were lethally irradiated and then immediately transplanted with bone marrow from either ACE 10/10 (10/10) or littermate WT mice. After engraftment, the mice were challenged subcutaneously with 1 × 109 MRSA. Four days later, mice were sacrificed, and bacterial burden in the skin lesion was determined. WT mice receiving bone marrow from ACE 10/10 mice (triangles) showed a significantly reduced bacteria burden in the skin lesion, compared with WT mice receiving WT bone marrow (circles) (n = 5). *, p < 0.05.