TABLE 1.
Proteins having the consensus GHKL ATPase domain in the UniProtKB database (Homo sapiens)
| Target | Activity | Location |
|---|---|---|
| DNA topoisomerase II | Disentangling of chromatin DNA | Nuclear |
| Hsp90 (class A1, A2, and B2) | Heat shock chaperone protein | Cytosolic |
| TRAP1 | Tumor necrosis factor-associated protein (Hsp90 family) | Mitochondrial |
| Gp96 | Heat shock protein | ER |
| MORC | Nuclear protein required for spermatogenesis | Nucleus (germ cells) |
| PDK family | Kinase responsible for the inactivation of the pyruvate dehydrogenase | Mitochondrial matrix |
| BCKDK | Branched chain ketoacid dehydrogenase kinase | Mitochondrial |
| MutL homolog 3 | DNA mismatch repair | Nuclear |
| PMS1 | DNA mismatch repair | Nuclear |
| MLH1 | DNA mismatch repair | Nuclear |
| PMS family | Postmeiotic segregation protein (mismatch repair proteins) | Nuclear |
| Mu-RMS-40.5/.10 | Hypothetical rhabdomyosarcoma antigen (mismatch repair proteins) | Nuclear |