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. 2010 Oct 4;285(50):39551–39563. doi: 10.1074/jbc.M110.114736

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© 2010 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 6. — Biological consequences of LRF/miR-28/miR-505/ASF/SF2 axis dysregulation. a–f, P2MEF were transfected with siRNA-Ct, siRNA-LRF (a), siRNA-ASF (b), miR-28 (c), miR-505 (d), d-Ct and d-28 (e), and d-505 (f). After 48 h, cells were trypsinized and seeded for different assays as described under ”Experimental Procedures.“ Graphs show the fold changes (negative and positive) in the number of proliferating, senescent, and apoptotic cells. Each value was obtained by dividing the percentage of cells transfected with si-LRF (a), si-ASF/SF2 (b), miR-28 (c), and miR-505 (d) versus cells transfected with si-Ct or by dividing the percentage of cells transfected with d-28 (e) and d-505 (f) versus cells transfected with d-Ct. Fold changes in a–d were calculated with respect to siRNA-Ct, whereas fold changes in e and f were calculated with respect to d-Ct. *, p < 0.05; **, p < 0.01; ***, p < 0.001.