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Proposed roles of the LRF/miR-28/miR-505/ASF/SF2 axis (modified from Ref. 8). The modulation of miR-28 and miR-505 induced by LRF up- or down-regulation affects ASF/SF2 level and reinforces the role of LRF in MEF proliferation, senescence, and apoptosis. Dashed lines indicate loss of repression. Smaller forms indicate protein/miRNA decrease.
