FIGURE 10.

Schematic representation of CGN and TNF-α pathways. The CGN and TNF-α inflammatory pathways intersect to increase phospho-NIK and nuclear RelB and p52, consistent with a synergistic impact on the IKKα-mediated, non-canonical NF-κB pathway of inflammation. In contrast, the effect of CGN and TNF-α in combination reduced caspase-8 and PARP-1 fragmentation, indicating inhibition of TNF-α-induced apoptosis. This antiapoptotic effect may be attributable to CGN inhibition of the extrinsic pathway of apoptosis by reduction of Fas.