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Effects of proteasomal inhibitor MG-132. A, when cells were exposed to MG-132 (20 mm x 2 h) prior to exposure to CGN, TNF-α, or the combination of CGN and TNF-α, proteasomal inhibition completely reversed the increases in IL-8. B, in contrast, the increases in the PARP-1 89-kDa fragment that followed TNF-α or combined TNF-α + CGN exposures persisted when proteasomal processing was inhibited (p < 0.001, one-way ANOVA with Tukey-Kramer post-test). ***, p ≤ 0.001. Error bars, S.D.
