TABLE 4.
Substrate specificity of PepDWT and PepDCAT for 10 Xaa-His dipeptides, 2 His-Xaa dipeptides, and 2 His-containing tripepides
Values are expressed as relative activity setting the degradation of PepDWT for carnosine to 100%.
| PepDWT | PepDCAT | |
|---|---|---|
| % | % | |
| l-Carnosine | 100 | 24.5 |
| α-Ala-His | 155.7 | 4.7 |
| Gly-His | 118.1 | 4.2 |
| Val-His | 117.2 | 5.5 |
| Leu-His | 157.5 | 3.7 |
| Ile-His | 146.1 | 5.8 |
| Tyr-His | 125 | 5.3 |
| Ser-His | 126.8 | 5.5 |
| His-Arg | 112.3 | 4.7 |
| His-Asp | 131.7 | 5.9 |
| β-Asp-His | 3.9 | 3.8 |
| l-Homocarnosine | 1.6 | 6.8 |
| Gly-His-Gly | 4.8 | 4.8 |
| Gly-Gly-His | 3.7 | 4.2 |