FIGURE 1.

Endogenous NGF-TrkA interactions are protective for RGCs during retinal degeneration. Quantification of surviving RGCs: A, at 14 days post-ON axotomy; B, at 42 days of chronic glaucoma. The density of RGCs in the untreated contralateral normal eye is 100%. In ON axotomy intravitreal injections of the indicated agents were done once immediately after ON axotomy, except for NGF, which was dosed immediately and at day 7 post-axotomy (2 times treatment). In glaucoma intravitreal injections were done at days 14 and 21 of glaucoma, with constant high IOP measured throughout the test.