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. 2010 Oct 18;285(50):38743–38750. doi: 10.1074/jbc.R110.193367

FIGURE 1.

FIGURE 1.

Steroid/nuclear receptor publications. A graphical analysis of publications on steroid/nuclear receptors as they relate to influential findings in the field is presented. Discoveries listed include identification of a receptor for estrogens (1962) (82), identification of estrogen stimulation of gene expression (1968–1972) (83, 84), molecular DNA cloning of the first gene (1972) (85), partial purification of NRs (1974) (86–88), identification of estrogen-responsive genes (1976) (89), identification of hormone-response elements (HRE) (1982) (90), cloning of the first full-length NRs (1985) (91), determination of the first x-ray crystal structure of NRs (1991) (92–94), development of the first nuclear receptor knock-out (KO) mouse (1993) (95), cloning of the first SRC (1995) (20), development of the first coactivator (CoA) knock-out mouse (1998) (60), and identification of metabolic functions (F(x)s) for nuclear receptors (1997) (96). These data were compiled from PubMed. The asterisk indicates a predicted estimate for the number of publications for 2010.