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Ile-402 in KV1. 2 channel is homologous to Ile-470 in Shaker. Amino acid sequence alignment of inner helices between KcsA, Shaker, KV1.2, and DIV-S6 of rNaV1.4 is shown. Underlines, residues homologous to Ile-1575 in rNaV1.4. Box, glycine hinge residues. Light Gray, residues homologous to Phe-103 in the KcsA channel.
