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. 2010 Oct 12;285(50):39481–39489. doi: 10.1074/jbc.M110.164731

FIGURE 1.

FIGURE 1.

EGFR forms predimers in the cell membrane. A, overview of the constructs used in this study. Full-length EGFR was fused to mGFP, in some constructs preceded by one or two FKBP dimerization domains. ΔICD, intracellular domain deletion. B, mGFP or EGFR-mGFP was expressed in different cell lines: NIH 3T3 2.2 fibroblasts (devoid of endogenous EGFR), Her14 cells (NIH 3T3 2.2 fibroblasts expressing ∼3 × 105 human EGFRs/cell), and A431 cells (expressing ∼2 × 106 EGFRs/cell). Values of rinf were measured and are expressed as fraction of rmono (S.E.). *, p < 0.005.