TABLE 1.

Intracellular dNTP and rNTP concentrations of primary human monocyte-derived macrophage and activated PBMCs as determined by LC-MS/MS

	Concentration
	dCTP	dGTP	dATP	TTP
	μm
Activated PBMC	3.67 ± 2.65	1.52 ± 1.01	9.22 ± 4.5	16.0 ± 5.25
Macrophages	0.07 ± 0.05	0.07 ± 0.05	0.04 ± 0.03	0.05 ± 0.04
-Fold difference	$\raisebox{1ex}{$1$}\!\left/ \!\raisebox{-1ex}{$52$}\right.$	$\raisebox{1ex}{$1$}\!\left/ \!\raisebox{-1ex}{$22$}\right.$	$\raisebox{1ex}{$1$}\!\left/ \!\raisebox{-1ex}{$231$}\right.$	$\raisebox{1ex}{$1$}\!\left/ \!\raisebox{-1ex}{$320$}\right.$

	Amount
	dCTP	dGTP	dATP	TTP
	pmol/106 cells
Activated PBMC	1.17 ± 0.85	0.49 ± 0.32	2.95 ± 1.46	4.85 ± 1.56
Macrophages	0.19 ± 0.13	0.18 ± 0.13	0.10 ± 0.07	0.13 ± 0.10

	Concentration
	CTP	GTP	ATP	UTP
	μm
Activated PBMC	182 ± 24	1,745 ± 128	6,719 ± 560	690 ± 100
Macrophages	25 ± 8	323 ± 95	1,124 ± 339	173 ± 47
-Fold difference	$\raisebox{1ex}{$1$}\!\left/ \!\raisebox{-1ex}{$7$}\right.$	⅕	⅙	1/4

	Amount
	CTP	GTP	ATP	UTP
	pmol/106 cells
Activated PBMC	58 ± 8	558 ± 41	2,150 ± 179	221 ± 32
Macrophages	66 ± 21	859 ± 253	2,990 ± 902	460 ± 124