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. Author manuscript; available in PMC: 2011 Dec 1.
Published in final edited form as: Pharm Res. 2010 Sep 8;27(12):2528–2543. doi: 10.1007/s11095-010-0256-x

Fig. 8.

Fig. 8

Effect of down-regulation of MPR4 DETon permeability of the BBB for drugs. 3H-AZT accumulation in perfused brains was measured 4 h following an i.p. injection of mice on Day 9. Animals were treated on Days 1, 3 and 5 with 50 μg of anti-MRP4 pDNA/pPAC/pLPEI polyplex (n=4–5).