Figure 4. Exercise failed to rescue the neurogenic deficit and decreased GCL volume in HD mice. (A) The number of BrdU⁺ cells was significantly increased in WTR as compared to all other groups; ** p<0.03 (S+L mice; WTS=13; WTR=15; HTS=12; HTR=12). HD mice (N=24) had significantly less cells than WT (N=28); *p<0.002. (B) The density of BrdU⁺ cells (BrdU⁺/mm³) was highest in WTR, ** p<0.02, and significantly reduced in HD mice compared to WT mice, * p<0.006. (C) The percentage of BrdU⁺/NeuN⁺ was greater in WT than HD mice, ** p<0.0001, and in HTR as compared to HTS mice; p<0.05.  (D) The total number of new neurons was significantly increased in WTR, ** p <0.01 versus all other groups, as well as in WT as compared to HD mice; * p<0.002. (E) GCL volume measurements showed a reduction in HD versus WT mice; * p<0.005. (F) The percentage of BrdU⁺ cells present in the hilus was less in WT than HD mice, * p<0.0001, and also less in HTR than in HTS mice; ** p<0.0007.  Data represents mean ± SEM.