Table 2.
Normal Chow | Normal Chow+Rosi | High Fat | High Fat+Rosi | |||||
---|---|---|---|---|---|---|---|---|
WT | HSL−/− | WT | HSL−/− | WT | HSL−/− | WT | HSL−/− | |
Glucose, mg/dl | 160±36 | 177±36* | 104±41 | 130±30 | 179±30 | 197±29 | 140±29 | 208±47.5* |
Triglyceride, mg/dl | 93±17 | 73±17* | 72±12 | 56±16 | 156±33 | 158±21 | 126±21 | 123.2±26.7 |
Total cholesterol, mg/dl | 175±45 | 141±17 | 127±29 | 150±21 | 203±70 | 227±25 | 173.0±39.1 | 206.7±69.3 |
FFA, mmol/l | 1.55±0.72 | 1.01±0.19* | 0.80±0.37 | 0.71±0.23 | 2.39±1.30 | 2.14±0.62 | 1.01±0.47 | 1.03±0.54 |
Insulin, fasted, ng/ml | 1.66±0.15 | 1.72±0.17 | 1.48±0.08 | 1.60±0.11 | 1.53±0.12 | 1.44±0.17 | 1.30±0.29 | 1.68±0.35 |
Adiponectin, μg/ml | 56.6±9.5 | 12.8±7.7** | 68.0±5.3 | 56.4±12.3 | 39.2±2.5 | 9.1±3.7** | 67.1±0.9 | 50.66±11.9 |
Results are means ± SE of mice on various diets for 16wks (n=8 in each group).
P <0.05,
P <0.01.
Comparisons are between HSL−/− and WT within each treatment group.