Table 2.

TMEM127 mutant tumors are transcriptionally enriched for kinase signaling pathway.

Gene Set (Pathway)	NOM p-val	FDR q-val
Tyrosine Kinase
GHa	0	0.032
PDGFb	0.002	0.052
Insulin	0.006	0.068
EGFc	0.006	0.074
IGF1d	0.004	0.075
Hypoxia	0.96	0.97

^agrowth hormone

^bplatelet-derived growth factor

^cepidermal growth factor

^dinsulin-derived growth factor

Summary of gene set enrichment analysis (GSEA) analysis performed on ranked genes according to the ratios of transcripts from TMEM127-mutant and TMEM127-wild-type pheochromocytomas. Gene sets (pathways) with a nominal P-value (NOM) <0.01 and a false discovery rate (FDR) of <0.1 were considered significant. Results of multiple kinase pathways are displayed and contrasted with a nonsignificant hypoxia gene set.