Figure 7.

The electrical activity of Golgi cells The Golgi cell shows response dynamics, which can support the cycles of activation and inactivation observed in various functional conditions (see Figs 5 and 6). A, the Golgi cell in vitro shows (1) pacemaker activity at around 7 Hz. In response to depolarisation (2), the Golgi cell shows high-frequency discharge with frequency adaptation. In response to hyperpolarisation (3), the Golgi cell shows sagging inward rectification followed by (4) rebound excitation. Bursts of activity are followed by (5) a silent pause. B, demonstration of the silent pause following a burst response to a mossy fibre stimulus (arrows in the inset). C, when stimulated with pulses repeated at different frequencies, the Golgi cell shows enhanced responses (faster and higher frequency spikes) at the resonant frequency of 6 Hz. The tracings are simulated from the models of Solinas et al. (2007a,b, 2010) and reproduce response behaviours reported in Dieudonné (1988), Forti et al. (2006) and Solinas et al. (2007a,b);.