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. 2010 Jun 25;588(Pt 19):3639–3655. doi: 10.1113/jphysiol.2010.189605

Figure 8.

Figure 8

The physiological consequences of Golgi cell activation Golgi cell activation has complex consequences for granular layer responses. A, a burst in a group of mossy fibres (MF) generates stronger and faster granule cell responses in the centre than in the surround of a granular layer field (the red profile represents the excitatory/inhibitory balance in a granular layer field activated by a group of MFs and regulated by Golgi cells; drawn after Mapelli & D’Angelo, 2007). B, a MF theta-burst stimulation (TBS) in a group of MFs generates more effectively LTP in the centre and LTD in the surround of the granular layer field. C, the raster plot shows that a diffused random stimulation of the MFs generates a coherent response of the granule cells (GrC) and of the Golgi cells (GoC). Synchronisation is due to parallel fibre feed-back inhibition. Crosscorrelograms (CCH) are shown for two GoCs and for all the granule cells and the Golgi cells in the network revealing their coherence. Data elaborated from the model of Solinas et al. (2010).