Fig. 5.

The cyclic phase-limit solutions describing the steady state progression in the relationship between growth factor and cytokine accumulation. In this analysis, time dependence was not included, thus eliminating the biokinetic rate differences between the three experimental input studies [36–38]. These scenarios were all run with constant scaling factors of ρ₁(T)=ρ₂(T)=1. Mechanical load components were constrained to (a) ξ₁(T)=ξ₂(T)=1.0, (b) ξ₁(T)=ξ₂(T)=25.0, and (c) ξ₁(T) = ξ₂(T) = 100.0. As development progresses during dimensionless culture time, the relative relationship loops clockwise as well as from the outward toward the central steady state condition until the mechanical stimulus disrupts the spiral progression, leading to an increase in growth factors with low cytokine levels, and presumably active ECM synthesis.