Table 1. Metabolic interplay parameters developed from a systems biology approach for describing nanoscale molecular homeostasis [31].

Parameter	Description	Relationship or value
α1	Synthesis rate of cytokines	α1=0.048+β 1
α2	Growth rate of growth factor (GF)	α2=0.044+β 2
β1	Decay rate of cytokines	${\beta }_1=\frac{1}{{\tau }_1}\left\{\frac{{\Omega }_2-G_{\text{ss}}}{G_{\text{ss}}+1-{\Omega }_2}\right\}$
β2	Natural decay rate of GF	${\beta }_2=\frac{1}{{\tau }_2}\left\{\frac{C_{\text{ss}}-{\Omega }_1}{{\Omega }_1-C_{\text{ss}}-1}\right\}$
Ω1	Pivotal parameter for GF	Css−1<Ω1<Css
Ω2	Pivotal parameter for cytokines	Gss<Ω2<Gss+1