Table 5.

CYP2D6 2×2 haplotype analysis results

Gene	Markers	Hap ID	Hap allele	Hap P#	Other P#	HapT#	Other T#	chisq	df	p-value	Fisher p-value
CYP2D6	P34S_C1111T_delT_A2638del	1_1_1_1	C_C_T_A	268	62	124	44	3.2126	1	0.0731	0.0641
CYP2D6	P34S_C1111T_delT_A2638del	1_1_1_2	C_C_T__	3	327	4	164	0.8402	1	0.3593	0.2329
CYP2D6	P34S_C1111T_delT_A2638del	1_1_2_1	C_C___A	3	327	1	167	0.0256	1	0.8730	1.0000
CYP2D6	P34S_C1111T_delT_A2638del	1_2_1_1	C_T_T_A	0	330	3	165	3.3214	1	0.0684	0.0379
CYP2D6	P34S_C1111T_delT_A2638del	2_1_1_1	T_C_T_A	56	274	36	132	1.1884	1	0.2756	0.2250

Table 5 includes all of the observed haplotypes for CYP2D6. In the 2×2 test, each CYP2D6 haplotype was individually tested for association with drug arm. The 2X2 chi-square analyses of CYP2D6 haplotypes show that only the haplotype containing the variant CyP2D6_C1111T was associated with arm, and this association was only of borderline significance (chi-square p-value=0.0684; Fisher p-value = 0.0379). Hap ID is the code for the haplotype (1 is the common allele and 2 is the alternate allele at a given site); Hap allele indicates the nucleotide at the 4 positions for that haplotype; HapP# is the count of the listed haplotype in the Placebo population; HapT# is the count of the listed haplotype in the Tamoxifen population; OtherP# is the count of all other haplotypes in the Placebo population; OtherT# is the count of all other haplotypes in the Tamoxifen population; df is degrees of freedom; p-value is the chi-square p-value.