Table 6.
Path analysis data for adjacent pairs of genes in the tamoxifen pathway
| Gene_from | Gene_to | P-Arm_ path_coefficient | T-ARM_path_coefficient |
|---|---|---|---|
| CYP1A1 | CYP2C9 | 0.37582 | 0.19467 |
| CYP1A1 | CYP2D6 | 0.45705 | 0.03860 |
| CYP1A1 | CYP3A4 | 0.73003 | 0.09393 |
| CYP2B6 | CYP3A4 | 0.10988 | 0.05998 |
| CYP2B6 | SULT1A2 | 0.07337 | 0.11505 |
| CYP2C19 | CYP2C9 | 0.05252 | 0.16268 |
| CYP2C19 | CYP2D6 | 0.00670 | 0.09601 |
| CYP2C19 | CYP3A4 | 0.15628 | 0.06293 |
| CYP2C19 | SULT1A2 | 0.13980 | 0.07118 |
| CYP2C9 | CYP2D6 | 0.64493 | −0.03500 |
| CYP2C9 | CYP3A4 | 0.74513 | 0.00783 |
| CYP2C9 | SULT1A2 | −0.71662 | 0.13883 |
| CYP2D6 | CYP2C9 | 0.60978 | 0.18663 |
| CYP2D6 | CYP3A4 | 0.57290 | −0.09122 |
| CYP2D6 | SULT1A2 | −0.72283 | −0.02498 |
| CYP3A4 | CYP2C9 | 1.01819 | 0.10743 |
| CYP3A4 | CYP2D6 | 0.82757 | 0.23461 |
| CYP3A4 | SULT1A2 | −0.50759 | −0.08482 |
Table 6: Path Analysis Data for Adjacent Pairs of Genes in the Tamoxifen pathway lists the results from the path analysis generated with the Scientific Applications Software (SAS) program according to the statistical methods described in the paper. The column headers, which are standard output from the SAS program, include: gene from and gene to - indicating the direction; the path-coefficient, which is used to determine significance at the <0.05 level, listed for each arm. All analyses were run at least 100 times to ensure consistent results. These data were used to generate the pathway diagrams shown in Figure 2.