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. 2010 Dec;186(4):1271–1283. doi: 10.1534/genetics.110.123133

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Figure 6.— — The substantial increase in M phase duration in APC/C mutants with monopolar mitosis is caused by SAC engagement. (A) MDF-2–GFP localization in one-cell–stage embryos of the indicated genotypes. Note that MDF-2–GFP accumulates for an extended period on chromatin of such-1(t1668) spd-5(RNAi) embryos. Time in min:sec relative to onset of NEBD. Arrowhead points to MDF-2–GFP enrichment on chromatin. (B) Duration of MDF-2–GFP enrichment on chromatin measured from NEBD. (C) Inactivation of the SAC through mdf-1 or mdf-2 depletion reduces M phase delay in hypomorphic APC/C mutants.