Table 1. Uptake and pharmacokinetics of [11C]methamphetamine in the various organs.
| Organ | Peak time | Half-peak clearance | Peak% Dose/cc | Organ weight% Dose organ | AUC |
| Plasma a AA C | 50 sec | 1.5 min | 0.014±0.0020.014±0.003 | 4500 grams a63%63% | 0.029±0.0040.030±0.003 |
| Lung AA C | 55 sec | 7 min | 0.025±0.005*0.019±0.007 | 1246 grams b31.2%23.7% | 0.393±0.069*0.294±0.082 |
| Heart AA C | 1 min | 16 min | 0.007±0.0030.007±0.001 | 365 grams2.55%2.55% | 0.259±0.0720.205±0.087 |
| Kidneys AA C | 3 min | 22 mi | 0.022±0.0040.022±0.005 | 305 grams b6.7%6.7% | 0.732±0.1250.720±0.167 |
| Pancreas (tail) AA C | 5 min | 50 min | 0.013±0.0020.015±0.002 | 144 grams1.9%2.2% | 0.518±0.2250.655±0.239 |
| Spleen AA C | 3.5 min | 30 min | 0.014±0.0020.013±0.002 | 156 grams2.2%2.0% | 0.513±0.1010.503±0.064 |
| Liver AA C | 30 min | >75 min | 0.014±0.0030.013±0.002 | 1677 grams23.5%21.8% | 0.871±0.2150.778±0.138 |
| Stomach AA C | 30 min | >75 min | 0.014±0.0070.017±0.005 | 330 grams4.6%5.6% | 0.855±0.2150.967±0.457 |
| Brain AA C | 9 min | >75 min | 0.006±0.0010.006±0.001 | 1600 grams9.6%9.6% | 0.371±0.0430.380±0.041 |
Measures correspond to: time to peak concentration (Peak time), time to half-peak clearance averaged across both groups and peak concentration (expressed as % dose per cc) and AUC for the time activity curves for the African Americans (AA) and for the Caucasians (C).
*Unpaired Student t test (two tail) p<0.05.
aThe plasma value was extrapolated to whole blood assuming a 55% plasma volume.
bReflects the total weight of both left and right organs. Note that the total percent of organ accumulation is greater than 100%; this is because the times at which the peak uptake and the clearance occurs differs among the organs. The weight of the organs corresponds to the average weights recorded from male autopsies [37]; except in brain, which corresponds to weights obtained with MRI38.