|
Invasive meningococcal disease
|
|
|
|
|
| All studies [25]–[34],[36]–[41],[84]
|
16 |
2.02 (1.52–2.69) |
68.5% (47.2–81.2) |
— |
| Laboratory-confirmed diagnosis [27],[28],[31]–[33],[39]
|
6 |
3.24 (1.72–6.13) |
63.5% (11.7–84.9) |
0.149 |
| Adjusted analysis [25]–[28],[30]–[34],[36]–[40]
|
11 |
2.18 (1.55–3.06) |
66.8% (37.3–82.4) |
0.500 |
| Unadjusted analysis [29],[30],[39]–[41]
|
5 |
1.78 (0.97–3.24) |
75.4% (32.1–84.7) |
0.500 |
| Adjusted for crowding, household density or room sharing [25],[27],[28],[32],[34],[36]–[38]
|
8 |
1.96 (1.36–2.82) |
67.7% (34.6–93.5) |
0.858 |
| Adjusted for vaccination status [26],[31],[36]
|
3 |
2.21 (1.41–3.46) |
48.6% (0–85.0) |
0.468 |
| Adjusted for breastfeeding [33],[34]
|
2 |
2.38 (0.19–29.32) |
87.4% |
0.894 |
| Age less than 6 y |
3 |
3.04 (0.88–10.47) |
79.4% (34.6–93.5) |
0.591 |
|
Meningococcal carriage
|
|
|
|
|
| All studies [54]–[58]
|
5 |
1.67 (1.12–2.52) |
61.6% (0–85.6) |
— |
| Adjusted analysis [57]
|
1 |
1.17 (1.05–1.30) |
— |
0.061 |
| Unadjusted analysis [54]–[56],[58]
|
4 |
2.07 (1.43–2.99) |
0% (0–84.7) |
0.061 |
|
Invasive pneumococcal disease
|
|
|
|
|
| All studies [35],[36],[42],[43]
|
4 |
1.21 (0.69–2.14) |
52.3% (0–84.2) |
— |
| Laboratory-confirmed diagnosis [36],[42],[43]
|
3 |
0.93 (0.62–1.41) |
0% (0–89.6) |
0.170 |
| Adjusted analysis [35]
|
1 |
2.99 (1.10–.8.14) |
— |
0.170 |
| Unadjusted analysis [36],[42],[43]
|
3 |
0.93 (0.62–1.41) |
0% (0–89.6) |
0.170 |
| Age less than 6 y [35],[42]
|
2 |
1.68 (0.61–4.66) |
62.4% |
0.461 |
| Studies prior to 2000 [35],[36],[43]
|
3 |
1.33 (0.58–3.02) |
68.1% (0–90.8) |
0.803 |
|
Pneumococcal carriage
|
|
|
|
|
| All studies [59]–[63]
|
5 |
1.66 (1.33–2.07) |
0% (0–79.2) |
— |
| Adjusted analysis [59],[60],[62]
|
3 |
1.48 (1.01–2.16) |
26.4% (0–92.4) |
0.519 |
| Unadjusted analysis [61],[63]
|
2 |
1.76 (1.34–2.31) |
0% |
0.519 |
| Age less than 6 y [60],[61],[63]
|
3 |
1.63 (1.27–2.01) |
12.7% (0–86.7) |
0.807 |
|
Invasive Hib disease
|
|
|
|
|
| All studies [3],[36],[44]–[53]
|
12 |
1.22 (0.93–1.62) |
55.0% (13.8–76.5) |
— |
| Laboratory-confirmed diagnosis [3],[36],[44],[46]–[50],[52],[53]
|
10 |
1.24 (0.86–1.78) |
62.7% (26.2–81.2) |
0.929 |
| Adjusted analysis [3],[36],[44],[47],[48],[50]–[52]
|
8 |
1.10 (0.80–1.51) |
56.5% (4.2–80.2) |
0.269 |
| Unadjusted analysis [45],[46],[49],[53]
|
4 |
1.70 (0.90–3.20) |
53.0% (0–84.6) |
0.269 |
| Adjusted for crowding, household density or room sharing [36],[44],[47],[48],[50],[51]
|
6 |
1.05 (0.76–1.46) |
52.3% (0–81.0) |
0.241 |
| Adjusted for vaccination status [36],[47],[50]
|
3 |
1.20 (0.70–2.04) |
66.9% (0–90.45) |
0.915 |
| Adjusted for breastfeeding [3],[47],[50],[52]
|
4 |
1.13 (0.63–1.98) |
69.2% (11.0–89.3) |
0.714 |
| Age less than 6 y [3],[36],[44]–[47],[49],[52],[53]
|
9 |
1.46 (1.19–1.81) |
38.5% (0–71.7) |
0.035 |
| Studies prior to 1990 [3],[44]–[47]
|
5 |
1.49 (1.16–1.93) |
44.9% (0–79.8) |
0.168 |
|
Hib carriage
|
|
|
|
|
| All studies [64],[65]
|
2 |
0.96 (0.48–1.95) |
0% |
— |
| Unadjusted analysis[65]
|
1 |
0.89 (0.42–1.89) |
— |
— |
