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. 2010 Nov 18;7:326. doi: 10.1186/1743-422X-7-326

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Copyright ©2010 Ie et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Alignment of amino acid sequences of HBV isolates in Indonesian blood donors with frequently-reported variants associated with failure of diagnostic assays. Three amino acid substitutions were identified in 7 HBV isolates in blood donors: Pattern 1, T123A, in one isolate; Pattern 2, M133L, in one isolate; Pattern 3, T143M, in five isolates. HBV DNA isolated from the remaining 18 samples showed wild type (wt) sequences with no amino acid substitution. Consensus of each of the three single mutation patterns and wt were aligned with five known variants frequently associated with problems in diagnostic assays and/or escape to vaccine/HBIg therapy: T123N, M133I, M133T, M133V, and T143L, together with M54923 sequence (genotype B/adw) retrieved from GenBank as a reference.