Table 3.

Top common pathways regulated by TNT in vitro and in vivo

Canonical Pathways	Common regulated genes*
Metabolism of Xenobiotics by Cytochrome P450	CYP3A43, CYP2F1, GSTP1, CYP1A1, CYP2C18, UGT1A6, UGT2B7, GSTA5, ALDH1L1, UGT2B17, EPHX1
NRF2-mediated Oxidative Stress Response	GSR, AKR7A3, GSTP1, MAPK1, GSTA5, NQO1, GCLC, SQSTM1, DNAJB6, MAFF, TXNRD1, EPHX1
Xenobiotic Metabolism Signaling	GSTP1, CYP1A1, UGT1A6, MAPK1, GSTA5, NQO1, ALDH1L1, GCLC, CES2 (includes EG:8824), UGT2B7, NR1I3, UGT2B17, ABCC3
Aryl Hydrocarbon Receptor Signaling	MYC, GSTP1, CYP1A1, CCND2, MAPK1, GSTA5, NQO1, RARB, ALDH1L1
Pentose and Glucuronate Interconversions	TCAG7.1260, AKR7A3, UGDH, UGT1A6, UGT2B7, UGT2B17
LPS/IL-1 Mediated Inhibition of RXR Function	GSTP1, ABCG5, CPT1A, GSTA5, NR1I3, ALDH1L1, CES2 (includes EG:8824), ABCC3, ABCC4
Glutathione Metabolism	GSR, GSTP1, GSTA5, H6PD, GCLC
PXR/RXR Activation	CPT1A, NR1I3, CES2 (includes EG:8824), ABCC3

* Full names of the genes are listed in Additional file 1, Table S 1