Table 2.
Overview of MHC class II binding dataset utilized in the present study.
| Allelic variant | # of binding affinities | # of binders1 | % of binders | Allele frequency2 |
|---|---|---|---|---|
| HLA-DPA1*0201-DPB1*0101 | 1399 | 702 | 0.5 | 16.0 |
| HLA-DPA1*0103-DPB1*0201 | 1404 | 635 | 0.45 | 17.5 |
| HLA-DPA1*01-DPB1*0401 | 1337 | 540 | 0.4 | 36.2 |
| HLA-DPA1*0301-DPB1*0402 | 1407 | 621 | 0.44 | 41.6 |
| HLA-DPA1*0201-DPB1*0501 | 1410 | 528 | 0.37 | 21.7 |
| HLA-DQA1*0501-DQB1*0201 | 1658 | 742 | 0.45 | 11.3 |
| HLA-DQA1*0501-DQB1*0301 | 1689 | 1023 | 0.61 | 35.1 |
| HLA-DQA1*0301-DQB1*0302 | 1719 | 670 | 0.39 | 19.0 |
| HLA-DQA1*0401-DQB1*0402 | 1701 | 731 | 0.43 | 12.8 |
| HLA-DQA1*0101-DQB1*0501 | 1739 | 687 | 0.4 | 14.6 |
| HLA-DQA1*0102-DQB1*0602 | 1629 | 974 | 0.6 | 14.6 |
| HLA-DRB1*0101 | 6427 | 4519 | 0.7 | 5.4 |
| HLA-DRB1*0301 | 1715 | 553 | 0.32 | 13.7 |
| HLA-DRB1*0401 | 1769 | 978 | 0.55 | 4.6 |
| HLA-DRB1*0404 | 577 | 396 | 0.69 | 3.6 |
| HLA-DRB1*0405 | 1582 | 806 | 0.51 | 6.2 |
| HLA-DRB1*0701 | 1745 | 1033 | 0.59 | 13.5 |
| HLA-DRB1*0802 | 1520 | 591 | 0.39 | 4.9 |
| HLA-DRB1*0901 | 1520 | 815 | 0.54 | 6.2 |
| HLA-DRB1*1101 | 1794 | 957 | 0.53 | 11.8 |
| HLA-DRB1*1302 | 1580 | 656 | 0.42 | 7.7 |
| HLA-DRB1*1501 | 1769 | 909 | 0.51 | 12.2 |
| HLA-DRB3*0101 | 1501 | 426 | 0.28 | 26.1 |
| HLA-DRB4*0101 | 1521 | 654 | 0.43 | 41.8 |
| HLA-DRB5*0101 | 1769 | 992 | 0.56 | 16.0 |
| H-2-IAb | 660 | 180 | 0.27 | - |
| Total | 44541 | 22318 | ||
| Min | 577 | 180 | ||
| Max | 6427 | 4519 | ||
| DP | 92.6 | |||
| DQ | 81.6 | |||
| DRB1 | 71.0 | |||
| DRB3/4/5 | 70.9 | |||
| Total | 99.9 | |||
1. Binder defined as IC50 <1000 nM.
2. Average haplotype and phenotype frequencies for individual alleles are based on data available at dbMHC. dbMHC data considers prevalence in Europe, North Africa, North-East Asia, the South Pacific (Australia and Oceania), Hispanic North and South America, American Indian, South-East Asia, South-West Asia, and Sub-Saharan Africa populations. DP, DRB1 and DRB3/4/5 frequencies consider only the beta chain frequency, given that the DRA chain is largely monomorphic, and that differences in DPA are not hypothesized to significantly influence binding. Frequency data are not available for DRB3/4/5 alleles. However, because of linkage with DRB1 alleles, coverage for these specificities may be assumed as follows: DRB3 with DR3, DR11, DR12, DR13 and DR14; DRB4 with DR4, DR7 and DR9; DRB5 with DR15 and DR16. Specific allele frequencies at each B3/B4/B5 locus is based on published associations with various DRB1 alleles, and assumes only limited variation at the indicated locus.