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The sources of IL-21. Both NKT cells and CD4 T cells have been shown to produce IL-21. Within the CD4 T cell population, Th17 and Tfh are the most prominent producers, whereas IL-21 is not secreted by CD4 Treg cells. CD8 T cell responses are not commonly associated with IL-21 production, although a limited number of studies indicate that this can occur.
