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. Author manuscript; available in PMC: 2012 Apr 1.
Published in final edited form as: Synapse. 2010 Sep 24;65(4):300–308. doi: 10.1002/syn.20848

Figure 4.

Figure 4

Pre-treatment with the neurokinin-1 receptor antagonist WIN-51,708 attenuated the METH-induced trafficking of the neurokinin-1 receptors. Mice received vehicle or a single injection of WIN-51,708 (5 mg/kg, i.p.) prior to METH (30 mg/kg, i.p.) and were sacrificed 30 minutes after the METH injection. Coronal sections through the striatum were processed for immunofluorescence for the neurokinin-1 receptor (FITC, green) and somatostatin (Cy3, red). A–D show a representative neuron from each condition. V/S, vehicle/saline (A); W/S, WIN-51,708/saline (B); V/M, vehicle/METH (C); W/M, WIN-51,708/METH (D). Note that blockade of the neurokinin-1 receptor with WIN-51,708 significantly attenuated the METH-induced trafficking of the neurokinin-1 receptors. Photomicrographs were obtained with the confocal microscope. Images are shown in dark field for greater contrast. Scale bar: 10 µm. (n = 6)